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KMID : 0811720080120060343
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Korean Journal of Physiology & Pharmacology
2008 Volume.12 No. 6 p.343 ~ p.348
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The Effect of Caffeic Acid on Wound Healing in Skin-incised Mice
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Song Ho-Sun
Sohn Uy-Dong
Shin Yong-Kyoo
Park Tae-Wook
Choi Byung-Chul
Kim Chang-Jong
Sim Sang-Soo
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Abstract
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This study was carried out to investigate the wound healing effect of caffeic acid in skin-incised mice. Caffeic acid showed significant effects on anti-inflammatory activity and wound healing, such as myeloperoxidase activity, lipid peroxidation, phospholipase A2 activity and collagen-like polymer synthesis, in incised-wound tissue. On the other hand, it significantly stimulated collagen-like polymer synthesis in NIH 3T3 fibroblast cells, while inhibited both silica-induced reactive oxygen species generation and melittin-induced arachidonic acid release and PGE2 production in Raw 264.7 cells, and histamine release in RBL 2H3 cells stimulated by melittin or arachidonic acid. Therefore, caffeic acid appears to have a potent antioxidant and anti-inflammatory effect in cell culture system, which may be related to wound healing in skin-incised mice.
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KEYWORD
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Caffeic acid, Histamine, Arachidonic acid, Collagen, Wound healing
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